Parker Lab at the University of Minnesota

Our lab uses peptide chemical biology, nanotechnology and proteomics to develop biosensors for intracellular phosphorylation signaling. We use synthetic peptide and protein chemistry to design probes for multiplexed analysis of cancer-related signaling proteins e.g. c-Abl, other Src-family kinases, receptor tyrosine kinases, etc. We are exploring a wide variety of multidisciplinary analytical methods including mass spectrometry, fluorescence microscopy and Raman spectroscopy to monitor these signaling proteins and their activities. Our technology development is leading us to new ways to asking increasingly complex questions about multiple signaling activities, their disruption in cancer, and response of signaling profiles to cancer treatment.